FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition.
Identifieur interne : 000848 ( Main/Exploration ); précédent : 000847; suivant : 000849FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition.
Auteurs : Céline Barthelemy [Belgique] ; Abdoulaye Oury Barry [Belgique] ; Laure Twyffels [Belgique] ; Bruno André [Belgique]Source :
- Scientific reports [ 2045-2322 ] ; 2017.
Descripteurs français
- KwdFr :
- Cellules HeLa (MeSH), Chlorhydrate de fingolimod (pharmacologie), Complexe-1 cible mécanistique de la rapamycine (antagonistes et inhibiteurs), Endocytose (effets des médicaments et des substances chimiques), Endocytose (physiologie), Humains (MeSH), Immunosuppresseurs (pharmacologie), Membrane cellulaire (métabolisme), Saccharomyces cerevisiae (effets des médicaments et des substances chimiques), Saccharomyces cerevisiae (métabolisme), Systèmes de transport d'acides aminés (métabolisme), Transduction du signal (MeSH), Transport des protéines (MeSH), Ubiquitination (MeSH).
- MESH :
- antagonistes et inhibiteurs : Complexe-1 cible mécanistique de la rapamycine.
- effets des médicaments et des substances chimiques : Endocytose, Saccharomyces cerevisiae.
- métabolisme : Membrane cellulaire, Saccharomyces cerevisiae, Systèmes de transport d'acides aminés.
- pharmacologie : Chlorhydrate de fingolimod, Immunosuppresseurs.
- physiologie : Endocytose.
- Cellules HeLa, Humains, Transduction du signal, Transport des protéines, Ubiquitination.
English descriptors
- KwdEn :
- Amino Acid Transport Systems (metabolism), Cell Membrane (metabolism), Endocytosis (drug effects), Endocytosis (physiology), Fingolimod Hydrochloride (pharmacology), HeLa Cells (MeSH), Humans (MeSH), Immunosuppressive Agents (pharmacology), Mechanistic Target of Rapamycin Complex 1 (antagonists & inhibitors), Protein Transport (MeSH), Saccharomyces cerevisiae (drug effects), Saccharomyces cerevisiae (metabolism), Signal Transduction (MeSH), Ubiquitination (MeSH).
- MESH :
- chemical , antagonists & inhibitors : Mechanistic Target of Rapamycin Complex 1.
- chemical , metabolism : Amino Acid Transport Systems.
- drug effects : Endocytosis, Saccharomyces cerevisiae.
- metabolism : Cell Membrane, Saccharomyces cerevisiae.
- chemical , pharmacology : Fingolimod Hydrochloride, Immunosuppressive Agents.
- physiology : Endocytosis.
- HeLa Cells, Humans, Protein Transport, Signal Transduction, Ubiquitination.
Abstract
FTY720 is a sphingoid base analog that acts as an anticancer agent in animal models. Its effect on tumor cells stems largely from its ability to trigger endocytosis of several nutrient transporters. The observation that FTY720 similarly stimulates downregulation of amino acid permeases in yeast suggests that the cellular mechanisms it targets, which are still poorly characterized, are evolutionarily conserved. We here report that adding FTY720 to yeast cells results in rapid inhibition of the intrinsic activity of multiple permeases. This effect is associated with inhibition of the TORC1 kinase complex, which in turn promotes ubiquitin-dependent permease endocytosis. Further analysis of the Gap1 permease showed that FTY720 elicits its ubiquitylation via the same factors that promote this modification when TORC1 is inhibited by rapamycin. We also show that FTY720 promotes endocytosis of the LAT1/SLC7A5 amino acid transporter in HeLa cells, this being preceded by loss of its transport activity and by mTORC1 inhibition. Our data suggest that in yeast, TORC1 deactivation resulting from FTY720-mediated inhibition of membrane transport elicits permease endocytosis. The same process seems to occur in human cells even though our data and previous reports suggest that FTY720 promotes transporter endocytosis via an additional mechanism insensitive to rapamycin.
DOI: 10.1038/s41598-017-14124-2
PubMed: 29062000
PubMed Central: PMC5653847
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition.</title><author><name sortKey="Barthelemy, Celine" sort="Barthelemy, Celine" uniqKey="Barthelemy C" first="Céline" last="Barthelemy">Céline Barthelemy</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Physiology of the Cell, Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Molecular Physiology of the Cell, Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies</wicri:regionArea><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Barry, Abdoulaye Oury" sort="Barry, Abdoulaye Oury" uniqKey="Barry A" first="Abdoulaye Oury" last="Barry">Abdoulaye Oury Barry</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Physiology of the Cell, Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Molecular Physiology of the Cell, Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies</wicri:regionArea><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Twyffels, Laure" sort="Twyffels, Laure" uniqKey="Twyffels L" first="Laure" last="Twyffels">Laure Twyffels</name><affiliation wicri:level="4"><nlm:affiliation>Center for Microscopy and Molecular Imaging (CMMI), Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Microscopy and Molecular Imaging (CMMI), Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies</wicri:regionArea><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Andre, Bruno" sort="Andre, Bruno" uniqKey="Andre B" first="Bruno" last="André">Bruno André</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Physiology of the Cell, Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies, Belgium. Bruno.Andre@ulb.ac.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Molecular Physiology of the Cell, Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies</wicri:regionArea><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29062000</idno><idno type="pmid">29062000</idno><idno type="doi">10.1038/s41598-017-14124-2</idno><idno type="pmc">PMC5653847</idno><idno type="wicri:Area/Main/Corpus">000696</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000696</idno><idno type="wicri:Area/Main/Curation">000696</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000696</idno><idno type="wicri:Area/Main/Exploration">000696</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition.</title><author><name sortKey="Barthelemy, Celine" sort="Barthelemy, Celine" uniqKey="Barthelemy C" first="Céline" last="Barthelemy">Céline Barthelemy</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Physiology of the Cell, Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Molecular Physiology of the Cell, Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies</wicri:regionArea><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Barry, Abdoulaye Oury" sort="Barry, Abdoulaye Oury" uniqKey="Barry A" first="Abdoulaye Oury" last="Barry">Abdoulaye Oury Barry</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Physiology of the Cell, Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Molecular Physiology of the Cell, Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies</wicri:regionArea><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Twyffels, Laure" sort="Twyffels, Laure" uniqKey="Twyffels L" first="Laure" last="Twyffels">Laure Twyffels</name><affiliation wicri:level="4"><nlm:affiliation>Center for Microscopy and Molecular Imaging (CMMI), Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Microscopy and Molecular Imaging (CMMI), Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies</wicri:regionArea><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Andre, Bruno" sort="Andre, Bruno" uniqKey="Andre B" first="Bruno" last="André">Bruno André</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Physiology of the Cell, Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies, Belgium. Bruno.Andre@ulb.ac.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Molecular Physiology of the Cell, Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies</wicri:regionArea><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author></analytic><series><title level="j">Scientific reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Transport Systems (metabolism)</term><term>Cell Membrane (metabolism)</term><term>Endocytosis (drug effects)</term><term>Endocytosis (physiology)</term><term>Fingolimod Hydrochloride (pharmacology)</term><term>HeLa Cells (MeSH)</term><term>Humans (MeSH)</term><term>Immunosuppressive Agents (pharmacology)</term><term>Mechanistic Target of Rapamycin Complex 1 (antagonists & inhibitors)</term><term>Protein Transport (MeSH)</term><term>Saccharomyces cerevisiae (drug effects)</term><term>Saccharomyces cerevisiae (metabolism)</term><term>Signal Transduction (MeSH)</term><term>Ubiquitination (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Cellules HeLa (MeSH)</term><term>Chlorhydrate de fingolimod (pharmacologie)</term><term>Complexe-1 cible mécanistique de la rapamycine (antagonistes et inhibiteurs)</term><term>Endocytose (effets des médicaments et des substances chimiques)</term><term>Endocytose (physiologie)</term><term>Humains (MeSH)</term><term>Immunosuppresseurs (pharmacologie)</term><term>Membrane cellulaire (métabolisme)</term><term>Saccharomyces cerevisiae (effets des médicaments et des substances chimiques)</term><term>Saccharomyces cerevisiae (métabolisme)</term><term>Systèmes de transport d'acides aminés (métabolisme)</term><term>Transduction du signal (MeSH)</term><term>Transport des protéines (MeSH)</term><term>Ubiquitination (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Mechanistic Target of Rapamycin Complex 1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Amino Acid Transport Systems</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Complexe-1 cible mécanistique de la rapamycine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Endocytosis</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Endocytose</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Membrane</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Membrane cellulaire</term><term>Saccharomyces cerevisiae</term><term>Systèmes de transport d'acides aminés</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Chlorhydrate de fingolimod</term><term>Immunosuppresseurs</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Fingolimod Hydrochloride</term><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Endocytose</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Endocytosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>HeLa Cells</term><term>Humans</term><term>Protein Transport</term><term>Signal Transduction</term><term>Ubiquitination</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules HeLa</term><term>Humains</term><term>Transduction du signal</term><term>Transport des protéines</term><term>Ubiquitination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">FTY720 is a sphingoid base analog that acts as an anticancer agent in animal models. Its effect on tumor cells stems largely from its ability to trigger endocytosis of several nutrient transporters. The observation that FTY720 similarly stimulates downregulation of amino acid permeases in yeast suggests that the cellular mechanisms it targets, which are still poorly characterized, are evolutionarily conserved. We here report that adding FTY720 to yeast cells results in rapid inhibition of the intrinsic activity of multiple permeases. This effect is associated with inhibition of the TORC1 kinase complex, which in turn promotes ubiquitin-dependent permease endocytosis. Further analysis of the Gap1 permease showed that FTY720 elicits its ubiquitylation via the same factors that promote this modification when TORC1 is inhibited by rapamycin. We also show that FTY720 promotes endocytosis of the LAT1/SLC7A5 amino acid transporter in HeLa cells, this being preceded by loss of its transport activity and by mTORC1 inhibition. Our data suggest that in yeast, TORC1 deactivation resulting from FTY720-mediated inhibition of membrane transport elicits permease endocytosis. The same process seems to occur in human cells even though our data and previous reports suggest that FTY720 promotes transporter endocytosis via an additional mechanism insensitive to rapamycin.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29062000</PMID><DateCompleted><Year>2019</Year><Month>07</Month><Day>12</Day></DateCompleted><DateRevised><Year>2019</Year><Month>07</Month><Day>12</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2045-2322</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>10</Month><Day>23</Day></PubDate></JournalIssue><Title>Scientific reports</Title><ISOAbbreviation>Sci Rep</ISOAbbreviation></Journal><ArticleTitle>FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition.</ArticleTitle><Pagination><MedlinePgn>13816</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41598-017-14124-2</ELocationID><Abstract><AbstractText>FTY720 is a sphingoid base analog that acts as an anticancer agent in animal models. Its effect on tumor cells stems largely from its ability to trigger endocytosis of several nutrient transporters. The observation that FTY720 similarly stimulates downregulation of amino acid permeases in yeast suggests that the cellular mechanisms it targets, which are still poorly characterized, are evolutionarily conserved. We here report that adding FTY720 to yeast cells results in rapid inhibition of the intrinsic activity of multiple permeases. This effect is associated with inhibition of the TORC1 kinase complex, which in turn promotes ubiquitin-dependent permease endocytosis. Further analysis of the Gap1 permease showed that FTY720 elicits its ubiquitylation via the same factors that promote this modification when TORC1 is inhibited by rapamycin. We also show that FTY720 promotes endocytosis of the LAT1/SLC7A5 amino acid transporter in HeLa cells, this being preceded by loss of its transport activity and by mTORC1 inhibition. Our data suggest that in yeast, TORC1 deactivation resulting from FTY720-mediated inhibition of membrane transport elicits permease endocytosis. The same process seems to occur in human cells even though our data and previous reports suggest that FTY720 promotes transporter endocytosis via an additional mechanism insensitive to rapamycin.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Barthelemy</LastName><ForeName>Céline</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Molecular Physiology of the Cell, Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barry</LastName><ForeName>Abdoulaye Oury</ForeName><Initials>AO</Initials><AffiliationInfo><Affiliation>Molecular Physiology of the Cell, Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Twyffels</LastName><ForeName>Laure</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Center for Microscopy and Molecular Imaging (CMMI), Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>André</LastName><ForeName>Bruno</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Molecular Physiology of the Cell, Université libre de Bruxelles (ULB), IBMM (Biopark), Gosselies, Belgium. Bruno.Andre@ulb.ac.be.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>10</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Sci Rep</MedlineTA><NlmUniqueID>101563288</NlmUniqueID><ISSNLinking>2045-2322</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D026905">Amino Acid Transport Systems</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D000076222">Mechanistic Target of Rapamycin Complex 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>G926EC510T</RegistryNumber><NameOfSubstance UI="D000068876">Fingolimod Hydrochloride</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D026905" MajorTopicYN="N">Amino Acid Transport Systems</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002462" MajorTopicYN="N">Cell Membrane</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004705" MajorTopicYN="N">Endocytosis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000068876" MajorTopicYN="N">Fingolimod Hydrochloride</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006367" MajorTopicYN="N">HeLa Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007166" MajorTopicYN="N">Immunosuppressive Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000076222" MajorTopicYN="N">Mechanistic Target of Rapamycin Complex 1</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D021381" MajorTopicYN="N">Protein Transport</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054875" MajorTopicYN="N">Ubiquitination</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>07</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>10</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>10</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>7</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29062000</ArticleId><ArticleId IdType="doi">10.1038/s41598-017-14124-2</ArticleId><ArticleId IdType="pii">10.1038/s41598-017-14124-2</ArticleId><ArticleId IdType="pmc">PMC5653847</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Biol Chem. 2003 Jul 18;278(29):26976-82</Citation><ArticleIdList><ArticleId IdType="pubmed">12709439</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Drug Discov. 2010 Nov;9(11):883-97</Citation><ArticleIdList><ArticleId IdType="pubmed">21031003</ArticleId></ArticleIdList></Reference><Reference><Citation>Elife. 2013 Apr 16;2:e00459</Citation><ArticleIdList><ArticleId IdType="pubmed">23599894</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Biochem Cell Biol. 2015 Oct;67:25-33</Citation><ArticleIdList><ArticleId IdType="pubmed">26256001</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2002 Apr 12;296(5566):346-9</Citation><ArticleIdList><ArticleId IdType="pubmed">11923495</ArticleId></ArticleIdList></Reference><Reference><Citation>Traffic. 2006 Aug;7(8):1045-59</Citation><ArticleIdList><ArticleId IdType="pubmed">16734661</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17402-7</Citation><ArticleIdList><ArticleId IdType="pubmed">18981422</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2001 Nov 23;276(47):43939-48</Citation><ArticleIdList><ArticleId IdType="pubmed">11500493</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Sci (Lond). 2016 Apr 1;130(7):499-512</Citation><ArticleIdList><ArticleId IdType="pubmed">26608079</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochim Biophys Acta. 2017 Apr;1861(4):727-736</Citation><ArticleIdList><ArticleId IdType="pubmed">28088504</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2014 Mar 7;289(10):7232-46</Citation><ArticleIdList><ArticleId IdType="pubmed">24448798</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Biol Cell. 2016 Dec 15;27(25):4043-4054</Citation><ArticleIdList><ArticleId IdType="pubmed">27798240</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Biol. 1980 Jun 5;139(4):691-704</Citation><ArticleIdList><ArticleId IdType="pubmed">6251229</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2014 Aug 8;289(32):22103-16</Citation><ArticleIdList><ArticleId IdType="pubmed">24942738</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem J. 2007 Aug 15;406(1):1-12</Citation><ArticleIdList><ArticleId IdType="pubmed">17645414</ArticleId></ArticleIdList></Reference><Reference><Citation>Traffic. 2013 Apr;14 (4):412-27</Citation><ArticleIdList><ArticleId IdType="pubmed">23305501</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Cell Biol. 2010 Apr;20(4):196-204</Citation><ArticleIdList><ArticleId IdType="pubmed">20138522</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Cancer Res. 2015 Mar 15;5(4):1281-94</Citation><ArticleIdList><ArticleId IdType="pubmed">26101697</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 2014 Apr 3;33(14):1776-87</Citation><ArticleIdList><ArticleId IdType="pubmed">23604129</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 1996 Feb 15;10(4):382-94</Citation><ArticleIdList><ArticleId IdType="pubmed">8600023</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Biol Cell. 2002 Jul;13(7):2276-88</Citation><ArticleIdList><ArticleId IdType="pubmed">12134068</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2016 Jan 1;351(6268):43-8</Citation><ArticleIdList><ArticleId IdType="pubmed">26449471</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Biol. 1999 Sep 20;146(6):1227-38</Citation><ArticleIdList><ArticleId IdType="pubmed">10491387</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell. 2007 Jun 8;26(5):663-74</Citation><ArticleIdList><ArticleId IdType="pubmed">17560372</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1999 Jan 29;274(5):3009-16</Citation><ArticleIdList><ArticleId IdType="pubmed">9915839</ArticleId></ArticleIdList></Reference><Reference><Citation>FEBS Lett. 2003 Jun 5;544(1-3):160-4</Citation><ArticleIdList><ArticleId IdType="pubmed">12782308</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2009 Feb 6;136(3):521-34</Citation><ArticleIdList><ArticleId IdType="pubmed">19203585</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Biol. 2012 Jan 23;196 (2):247-59</Citation><ArticleIdList><ArticleId IdType="pubmed">22249293</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Pharmacol. 2003 Apr;138(7):1303-12</Citation><ArticleIdList><ArticleId IdType="pubmed">12711631</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Immunol. 2013 May;14(5):500-8</Citation><ArticleIdList><ArticleId IdType="pubmed">23525088</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Biol Cell. 2007 Aug;18(8):3068-80</Citation><ArticleIdList><ArticleId IdType="pubmed">17553927</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Microbiol. 1995 Oct;18(1):77-87</Citation><ArticleIdList><ArticleId IdType="pubmed">8596462</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Microbiol. 2010 Jan;75(1):246-60</Citation><ArticleIdList><ArticleId IdType="pubmed">20002879</ArticleId></ArticleIdList></Reference><Reference><Citation>FEBS Lett. 2016 Apr;590(7):885-907</Citation><ArticleIdList><ArticleId IdType="pubmed">26938658</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochim Biophys Acta. 2001 Oct 1;1514(2):291-302</Citation><ArticleIdList><ArticleId IdType="pubmed">11557028</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 2012 Nov;32(22):4510-22</Citation><ArticleIdList><ArticleId IdType="pubmed">22966204</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2004 Aug 27;279(35):36720-31</Citation><ArticleIdList><ArticleId IdType="pubmed">15190065</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Mol Cell Biol. 2009 Jun;10 (6):398-409</Citation><ArticleIdList><ArticleId IdType="pubmed">19436320</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Res Int. 2012;2012:242764</Citation><ArticleIdList><ArticleId IdType="pubmed">22988512</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioorg Med Chem Lett. 2006 Jan 1;16(1):84-7</Citation><ArticleIdList><ArticleId IdType="pubmed">16236505</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem J. 2011 Oct 15;439(2):299-311</Citation><ArticleIdList><ArticleId IdType="pubmed">21767261</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochim Biophys Acta. 1966 Oct 31;127(2):325-38</Citation><ArticleIdList><ArticleId IdType="pubmed">5964977</ArticleId></ArticleIdList></Reference><Reference><Citation>Amino Acids. 2016 Apr;48(4):1045-58</Citation><ArticleIdList><ArticleId IdType="pubmed">26724922</ArticleId></ArticleIdList></Reference><Reference><Citation>J Physiol. 2013 Feb 1;591(3):609-25</Citation><ArticleIdList><ArticleId IdType="pubmed">23165769</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 2014 Dec;34(24):4447-63</Citation><ArticleIdList><ArticleId IdType="pubmed">25266656</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Transplant. 2004 Jul;4(7):1019-25</Citation><ArticleIdList><ArticleId IdType="pubmed">15196057</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Res. 2015 Dec;25(12 ):1299-313</Citation><ArticleIdList><ArticleId IdType="pubmed">26611634</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1998 Sep 11;273(37):23629-32</Citation><ArticleIdList><ArticleId IdType="pubmed">9726963</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1999 Jul 16;274(29):20313-7</Citation><ArticleIdList><ArticleId IdType="pubmed">10400653</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Biochem. 2012;81:231-59</Citation><ArticleIdList><ArticleId IdType="pubmed">22404628</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2004 Jan 22;427(6972):355-60</Citation><ArticleIdList><ArticleId IdType="pubmed">14737169</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2001 Sep 21;276(38):35614-21</Citation><ArticleIdList><ArticleId IdType="pubmed">11468289</ArticleId></ArticleIdList></Reference><Reference><Citation>Yeast. 1991 Aug-Sep;7(6):609-15</Citation><ArticleIdList><ArticleId IdType="pubmed">1767589</ArticleId></ArticleIdList></Reference><Reference><Citation>Traffic. 2012 Mar;13(3):468-82</Citation><ArticleIdList><ArticleId IdType="pubmed">22118530</ArticleId></ArticleIdList></Reference><Reference><Citation>FASEB J. 2004 Mar;18(3):551-3</Citation><ArticleIdList><ArticleId IdType="pubmed">14715694</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Biol Cell. 2011 Sep;22(17 ):3218-30</Citation><ArticleIdList><ArticleId IdType="pubmed">21757542</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Biol. 2016 Dec 4;428(24 Pt A):4765-4775</Citation><ArticleIdList><ArticleId IdType="pubmed">27664439</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2002 Jun 14;277(24):21453-7</Citation><ArticleIdList><ArticleId IdType="pubmed">11967257</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2016 Nov 1;126(11):4088-4102</Citation><ArticleIdList><ArticleId IdType="pubmed">27669461</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1998 Jan 30;273(5):2829-34</Citation><ArticleIdList><ArticleId IdType="pubmed">9446592</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Belgique</li></country><region><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bruxelles</li></settlement><orgName><li>Université libre de Bruxelles</li></orgName></list><tree><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Barthelemy, Celine" sort="Barthelemy, Celine" uniqKey="Barthelemy C" first="Céline" last="Barthelemy">Céline Barthelemy</name></region><name sortKey="Andre, Bruno" sort="Andre, Bruno" uniqKey="Andre B" first="Bruno" last="André">Bruno André</name><name sortKey="Barry, Abdoulaye Oury" sort="Barry, Abdoulaye Oury" uniqKey="Barry A" first="Abdoulaye Oury" last="Barry">Abdoulaye Oury Barry</name><name sortKey="Twyffels, Laure" sort="Twyffels, Laure" uniqKey="Twyffels L" first="Laure" last="Twyffels">Laure Twyffels</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000848 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000848 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= RapamycinFungusV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:29062000
|texte= FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:29062000" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RapamycinFungusV1
| This area was generated with Dilib version V0.6.38. |  |